三維人體組織醫(yī)學(xué)電磁仿真軟件平臺Sim4Life

    三維人體組織醫(yī)學(xué)電磁仿真軟件平臺Sim4Life 是由瑞士IT'IS基金會研發(fā)的，已獲得瑞士CTI醫(yī)療科技獎，Sim4Life平臺結(jié)合可計(jì)算人類模型、強(qiáng)大的物理解算器和先進(jìn)的組織模型，能直接分析人體真實(shí)世界和復(fù)雜技術(shù)設(shè)備，以及驗(yàn)證人體組織和解剖學(xué)環(huán)境之中的變化。Sim4Life采用高性能計(jì)算和直觀GUI架構(gòu)，能實(shí)現(xiàn)的多物理模擬，和無盡的定制加快研發(fā)活動，協(xié)助醫(yī)療及科研團(tuán)隊(duì)優(yōu)化醫(yī)療器械和治療方法，且同時符合安全性和有效性的要求。

    三維人體組織醫(yī)學(xué)電磁仿真軟件平臺Sim4Life運(yùn)作流程可分成MRI/CT 3D影像重建、解剖及產(chǎn)品模型導(dǎo)入(CAD)、多樣化解算器、組織和物理模型、直觀的分析及硬體驗(yàn)證等階段，能夠在取得多張電磁影像資料之后，快速進(jìn)行完整3D三維影像重建，再利用內(nèi)建產(chǎn)品模型，產(chǎn)生接近真實(shí)狀況的醫(yī)學(xué)電磁模擬資料。而且產(chǎn)品本身支持市面上常見的模型軟件，包含各種公開的人體解剖模型，能夠符合不同醫(yī)療環(huán)境的使用需求。

    三維人體組織醫(yī)學(xué)電磁仿真軟件平臺Sim4Life內(nèi)建為計(jì)算復(fù)雜問題所設(shè)計(jì)的運(yùn)算，包括EM、熱學(xué)、聲波和流體求解，醫(yī)療研究單位只要安裝在高效能電腦上，即可在短時間內(nèi)獲得運(yùn)算結(jié)果。此外，三維人體組織醫(yī)學(xué)電磁仿真軟件平臺Sim4Life本身便有灌注模型，組織損傷模型和神經(jīng)元模型，均是現(xiàn)今手術(shù)過程中使用頻率的元件，特別是軟件本身可透過簡單易于操作的圖形化三維介面，協(xié)助操作者完成定義問題、離散，模擬和分析等步驟，能讓模擬結(jié)果都更接近真實(shí)結(jié)果。

    三維人體組織醫(yī)學(xué)電磁仿真軟件平臺Sim4Life可精準(zhǔn)掌握病情狀況，實(shí)現(xiàn)客制化醫(yī)療訴求，能夠根據(jù)個體的差異，採取術(shù)前科學(xué)規(guī)劃、術(shù)中定位、術(shù)后準(zhǔn)確評估。Sim4Life平臺采用互動式動態(tài)建模方式，簡單易用的下拉式建模工具列，不僅便于輸入醫(yī)療設(shè)備產(chǎn)生的各種影像檔，而只需利用滑鼠即可做視角縮放變換，輕松完成全人體三維模型，順利完成適宜的治療方案規(guī)劃。Sim4Life平臺具備易于編寫的特性，加上擁有線上強(qiáng)大資料庫，用戶很容易產(chǎn)生適合自身醫(yī)療環(huán)境的工具庫，也能即時調(diào)整平臺的操作環(huán)境。所以軟件平臺推出至今，已有許多客戶以此平臺再創(chuàng)建了許多延伸應(yīng)用，如MRI線圈設(shè)計(jì)、造影解析度改量、人體模型開發(fā)等等，堪稱是打造客制化醫(yī)療的工具。

    以醫(yī)學(xué)上常見的超音波刀進(jìn)行肝臟腫瘤切除為例，過去在醫(yī)師動刀之前多只有平面影像圖可參考，只能約略掌握腫瘤位置與大小，因此手術(shù)成功率多半取決于醫(yī)師的經(jīng)驗(yàn)多寡，很容易因一時疏忽引發(fā)后續(xù)醫(yī)療糾紛。通過Sim4Life平臺的模擬軟件協(xié)助，醫(yī)師能在手術(shù)之前即了解腫瘤位置與體積大小，所以就算經(jīng)驗(yàn)較嫩的年輕醫(yī)師，亦能順利完成肝臟腫瘤切除的手術(shù)作業(yè)。尤其是護(hù)理人員也因能預(yù)知傷口大小，能在術(shù)后照顧準(zhǔn)備上更為充分，讓病患享有完善的照顧服務(wù)。再如電燒刀手術(shù)是另一種適合Sim4Life平臺協(xié)助的醫(yī)療手術(shù)，該手術(shù)是針對心血管病變進(jìn)行的治療方式，但電燒刀電流密度高低與血管壁上剪應(yīng)力分布息息相關(guān)。一旦電燒刀上的電流過大，便可能造成傷口出血過多，所以若能透過術(shù)前的模擬軟件協(xié)助，則有助于提高手術(shù)的成功率。

    Sim4Life平臺使得個性化醫(yī)療將不再是遙不可及的夢想，亦能降低醫(yī)療機(jī)械研究的成本，並符合各國法規(guī)的要求。特別是當(dāng)醫(yī)療團(tuán)隊(duì)能夠收集到更多資訊，為病人制訂專屬客制化醫(yī)療之后，不僅能創(chuàng)造出更好醫(yī)療效果，也能準(zhǔn)確后續(xù)預(yù)測治療結(jié)果，減少病患術(shù)后感染或藥物過敏的醫(yī)療糾紛，進(jìn)而讓寶貴醫(yī)療資源獲得利用。當(dāng)客制化醫(yī)療能夠逐步被實(shí)踐之后，立法機(jī)關(guān)也能制定一套更完善的治療準(zhǔn)質(zhì)，提升醫(yī)療照護(hù)品質(zhì)與水準(zhǔn)。在醫(yī)療觀念不斷提升之下，建構(gòu)一套完善的健康管理平臺，已成為現(xiàn)代醫(yī)療醫(yī)學(xué)的新趨勢。

一般來說，健康管理平臺上收集到的資料有兩大用途，首先是作為醫(yī)生治療前的評估參考，如用藥種類或是手術(shù)形式，其次則是將病歷資料轉(zhuǎn)換為更容易閱讀的可視化圖像。醫(yī)院或研究單位若能夠?qū)⑶笆鰞深愘Y料，輸入到多重物理模擬軟件Sim4Life時，則有助于新醫(yī)療技術(shù)開發(fā)，進(jìn)而為特定疾病研發(fā)出更有效的藥物或治療工具。

In silico

The digital revolution is extending the frontiers of medicine and medical technology. Computer modeling and simulation (CM&S), or in silico technologies, merge computational tools with biology to intuitively, precisely, and reproducibly perform complex analyses of life sciences applications.  With this emerging paradigm, experimental manipulations that are infeasible or impossible to conduct in real-life experiments can be created while maintaining experimental control: the perfect complement to in vivo and in vitro studies.

ZMT provides in silico solutions to the medical device industry. Our comprehensive simulation platform, Sim4Life, provides a powerful 3D validated biological and anatomical modeling environment for optimizing the effectiveness and performance of medical devices, improving patient safety, and discovering potential new treatments. Built from the ground up, Sim4Life provides smooth and fully automated or customizable workflows for applications ranging from exploratory research and medical device development to regulatory documentation for clinical trials and device certification.

we trust

Our software tools are thoroughly and continually verified to ensure their reliability and performance requirements as they evolve.

The same effort is on validation for our expanding portfolio of targeted life sciences models and applications.

ZMT also provides test systems for validation procedures that support complex requirements with software tools optimized for test and measurement systems.

At ZMT, we leverage the combined strength of our expertise, experience, cost-effective solutions, and commitment to long and fruitful client relationships to enhance your competitive advantage during the regulatory submission process.

Phantoms	Solvers & Tissue Models	Validation Hardware

Sim4Life

Sim4Life is the first computational life sciences platform integrating computable human phantoms with the most powerful physics solvers and the most advanced tissue models for directly analyzing biological real-world phenomena and complex technical devices in a 3D validated biological and anatomical environment.

All modeling capabilities from the segmentation of medical image data, anatomical and CAD model import, discretization and simulation to visualization and analysis are embedded and streamlined to offer the most versatile and efficient simulation environment possible.

At the core of Sim4Life are the computable, high-fidelity 3D Virtual Population (ViP) human anatomical models. Carefully selected to fully represent global variations in human anatomy, the fully posable, morphable, and validated ViP models along with the IT'IS tissue properties database depict 15 different body types with 120 vital anatomical features and over 300 precisely identified tissues and organs. Cited and applied in hundreds of published studies and papers, the ViP models and the IT'IS material parameter database are continually and meticulously updated, refined, and expanded.

Sim4Life is a revolutionary simulation platform, combining computable human phantoms with the most powerful physics solvers and the most advanced tissue models, for directly analyzing biological real-world phenomena and complex technical devices in a validated biological and anatomical environment. The Sim4Life platform also offers leading performance with all the features expected from a multiphysics CAE/TCAD platform. Watch the Sim4Life demo video!

Computable Human Phantoms	Physics Solvers
Sim4Life natively supports the Virtual Population ViP 3.0 models that include integrated posing and morphing tools. Other publicly available animal and human anatomical models are also supported. All tissues are linked to a continually updated physical properties database.	The powerful Sim4Life solvers are specifically developed for computationally complex problems; HPC accelerated for the latest computer clusters; and smoothly integrated in the most advanced coupling framework. The platform already includes EM, Thermal Acoustic, and Flow solvers.

Tissue Models	Framework
The integrated tissue models enable the modeling and analysis ofphysiological processes. Perfusion models, tissue damage models, and neuronal models are already included in the first release of Sim4Life.	The Sim4Life Framework efficiently facilitates all steps in complex multiphysics modeling, from defining the problem, discretizing, simulating, and analyzing to visualizing the results, with clarity and flexibility.

Sim4Life Platform 三維人體組織醫(yī)學(xué)電磁仿真軟件平臺Sim4Life組成

Computable Human Phantoms-ViP 3.0 可計(jì)算三維人體組織仿真軟件-ViP 3.0

At the core of Sim4Life is a comprehensive set of computable human phan0[toms empowered by the most powerful physics solvers and the most advanced tissue models, providing a realistic biological and anatomical;] environment for conducting fundamental mechanistic studies, testing the effectiveness and safety of medical devices and treatments, and supplementing clinical trials. Based on the Virtual

Population ViP3.0 models of the IT’IS Foundation at ETHZ, the computable phantoms are characterized to predict real-world biological and physiological phenomena for any defined patient population. All tissues are linked to a continually updated physical properties database.

The powerful Sim4Life meshers allow high fidelity discretization of the complex computable human phantoms combined with any implant or external device.  A complementary interactive morpher extends the demographic coverage of the parameterized anatomical models, e.g., to explore underrepresented or pathological anatomies in clinical trials. A flexible poser is also included with the models.  Physicians and biologists rigorously validate the models and the associated database. Comprehensive documentation for all natively supported computable human phantoms is available.

Key Features

Native support for the latest generation of the Virtual Population ViP3.0 Largest library of 3D high resolution CAD-based phantoms available on the market Grid-independent (not based on voxel data), CAD-based anatomical phantom data More than 15 full body anatomical human phantoms More than 10 anatomical head models (children, *****, male, female, European, Asian)
Large high-resolution CAD animal models (or voxels via Brooks AF Base voxel data) More than 10 small animal models (rat, mouse, young, *****, male, female, pregnant, etc.) High resolution head model with integrated detailed deep brain structures and anisotropy information Integrated generation of high quality surface models from voxel and image data
Posable anatomical models and support for the parameterization of additional models Interactive model morphing tool Generic birdcage CAD models Validated standard and measurement phantoms (e.g., SAM V4.5, Eli, CTIA/hands, DASY phantoms, etc.)

Physics Models 物理模型

P-EM-FDTD ：Electromagnetics Full Wave Solvers電磁全波段解算程序

The Electromagnetics Full Wave Solvers (P-EM-FDTD) enable accelerated full-wave, large-scale EM modeling (> billion voxels) using Yee discretization on geometrically adaptive, inhomogeneous, rectilinear meshes with conformal sub-cell correction and thin layer models, offering support for dispersive materials. The solvers also include many unique features for EM safety assessments (see IMSAFE).

Optimal simulation speed is achieved with native GPU and MPI accelerations, which were developed by our team that first introduced EM accelerated solvers together with Acceleware in 2006.

The unique bidirectional Huygens box approach overcomes the difficulties associated with models that extend across multiple scales and require strongly varying resolutions.

As the most frequently applied solvers in near-field dosimetry, they have been extensively validated and documented according to the IEEE/IEC 62704-1 standard as well as by comparisons with measured data (> 200 publications). Comprehensive documentation is available for Sim4Life.

 

Exclusive thermal damage and effect quantification models, e.g., T-CEM43, are included.

The P-THERMAL solvers have been extensively validated by comparison with analytically solvable cases, experimental measurements under controlled conditions, and in vivo measurements. Comprehensive documentation is available for Sim4Life. 

 

P-FLOW：Fluid Dynamics Solvers 流體動力學(xué)解算程序

 

The high performance computing enabled Fluid Dynamics Solvers (P-FLOW) facilitate the modeling of realistic physiological and pathological biofluidic scenarios in the presence and absence of vascular implants. The stationary and transient Navier-Stokes and Stokes equations are efficiently solved in parallel using a Schur-complement-preconditioned finite element method with runtime solver monitoring, advanced convergence criteria, adaptive time-stepping, tunable stabilization, and optional nondimensionalization. Watch the demo video!

The P-FLOW solvers feature a unique solution to model strongly-coupled fluid-structure interaction problems for medtech applications, e.g., for pulsating vasculature modeling. (coming soon)

Specialized boundary conditions for realistic blood flow modeling (e.g., developed flow) and initial conditions based on measured image data can be applied.

The solvers are comprehensively and continually validated by comparison with analytical solutions for selected problems, benchmark problems, and measurement data. Comprehensive documentation is available for Sim4Life.  

P-ACOUSTICS：Acoustics Solvers 聲學(xué)解算程序

The novel ultrasound solvers account for pressure wave propagation, density variations and jumps, non-linearity, and diffusivity losses that occur in human tissue.

The FNM-CHASM solver offers near real-time simulations of acoustic propagation in inhomogeneous setups.  

The P-ACOUSTICS solvers have been extensively validated and the associated uncertainties have been quantified using analytical solutions, benchmarks, and robotic 3D-scan hydrophone measurements in complex setups. Comprehensive documentation is available for Sim4Life.  

Tissue Models 組織模型

T-NEURO ：Neuronal Tissue Models 神經(jīng)組三維模型

The Neuronal Tissue Models (T-NEURO) enable the dynamic modeling of EM-induced neuronal activation, inhibition, and synchronization using either complex, multi-compartmental representations of axons, neurons, and neuronal networks with varying channel dynamics, or generic models. The solvers are ideal for studying interaction mechanisms, evaluating and optimizing neurostimulating devices, and assessing safety issues. Embedded geometrical and dynamical representation of neurons (soma, axon, and dendritic tree) generate physiologically functionalized anatomical models. (coming soon)

The SENN model (safety standards) and more complex  models can be applied inside whole-body models. The GUI facilitates the integration of other neuronal models from commonly used databases or independently derived models.

T-NEURO has been validated against published data and

ex vivo and in vivo measurements, and is continually advanced and validated.